MAGY Study
MAGY which was a multi-site study for Adolescent Girls and Young Women for future HIV vaccines and antibodies for prevention started in 2023.
The MAGY study in collaboration with IAVI was based in four countries namely Uganda (UVRI-IAVI), Zambia (CFHRZ), Kenya (KAVI-ICR) and South Africa (Aurum). The study focuses on AGYW from the ages of 15 to 24 years that are at risk of acquiring HIV and are living or working from around fishing communities.
It is made up of a prevention package that is given to the AGYW in terms of HIV prevention, STI management, GBV management as well as Sexual Reproductive health services. This study aims to explore the participation of AGYW in future trials as it deals with Adolescent Girls and Young Women from fishing communities around Lake Victoria. On top of that, the AGYW are provided a skills training program such as hairdressing, computer skills and hand crafts as capacity building.
The MAGY study along with the Social Behavioral Research component is as well made up of the clinical component that has mucosal sample collection; the use of soft cups, cytobrushes and vaginal swabs and Longitudinal Sub-study that includes Leukapheresis, Fine Needle Aspiration and Large Blood Draws.
- To investigate the factors that influence the design and participation in clinical trials of HIV vaccine and bnAb product candidates for AGYW.
- To establish AGYW clinical trial preparedness cohorts for the evaluation of enhanced broadly neutralizing antibodies as a long-acting injectable HIV prevention product.
- To characterize peripheral immune cells via the least invasive sampling approaches for assessment or prediction of the suitability of HIV vaccine candidates for AGYW.